![]() Genotyping tools show comparatively better prospects, and they are widely used for distinguishing microorganisms. Conventional phenotypic approaches pose many challenges, and they may misidentify a target, limiting their use. ![]() See Instructions for Authors for a complete description of levels of evidence.Identification and classification of beneficial microbes is of the highest significance in food science and related industries. The present review describes the scientific evidence related to dead space management with a focus on the currently available local antimicrobial strategies in the management of FRI. Furthermore, the literature presents a wide array of methods and guidelines with respect to the use of local antimicrobials. Local antimicrobial therapy has been widely studied in periprosthetic joint infection, without addressing the specific problems of FRI. For this reason, the use of locally delivered antimicrobials has gained attention not only for local antimicrobial activity but also for dead space management. Dead space management is therefore of critical importance. However, debridement is often associated with the formation of a dead space, which provides an ideal environment for bacteria and is a potential site for recurrent infection. Treatment success is associated with debridement of all dead and poorly vascularized tissue. The surgical management eradicates the local infectious focus and if necessary facilitates bone healing. Fracture-related infection (FRI) remains a challenging complication that imposes a heavy burden on orthopaedic trauma patients.
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